new study in mice sheds light on at least part of the reason for the insulin
resistance that can come from diets high in high-fructose corn syrup, a
sweetener found in most sodas and many other processed foods.
is much more readily metabolized to fat in the liver than glucose, and in the
process can lead to nonalcoholic fatty liver disease. NAFLD in turn leads to
hepatic insulin resistance and type II diabetes.
showed that mice fed a high-fructose diet could be protected from insulin
resistance if a gene known as transcriptional coactivator PPARg coactivator-1b
(PGC-1b) was "knocked down" in the animals' liver and fat tissue. PGC-1b
controls the activity of several other genes, including one responsible for
building fat in the liver. This suggests an important role for PGC-1b in the
pathogenesis of fructose-induced insulin resistance.
There’s no doubt in my mind that one of the primary fuels for this
epidemic is the excess consumption of high fructose corn syrup (HFCS). Several
studies over the past few years have also come to this conclusion, including
this latest study inCell
Metabolism,in which the
resistance is a common feature of the metabolic syndrome and type 2 diabetes
mellitus (T2DM). Both have reached epidemic proportions worldwide with the
global adoption of the westernized diet along with increased consumption of
fructose, stemming from the wide and increasing use of high-fructose corn
is well established that fructose is more lipogenic than glucose, and
high-fructose diets have been linked to hypertriglyceridemia, nonalcoholic
fatty liver disease (NAFLD), and insulin resistance.”
Unfortunately, this study does nothing to further the return to a more
sane approach to health, but will likely just create even more problems as
they propose their findings could lead to yet another drug treatment to hamper
the harmful effects of HFCS consumption.
Absolutely in line with the drug model, and one has to seriously
wonder if they weren’t behind this study.
The answer is clearly not to create more drugs to combat the problem
of diabetes, but rather to educate the public about healthier eating habits –
which includes AVOIDING high fructose corn syrup as much as possible.
Scientists have clearly linked the rising HFCS consumption to the
epidemics of obesity,diabetesandmetabolic
syndromein the U.S., and
medical researchers have pinpointed various health dangers associated with the
consumption of HFCS compared to regular sugar.
are about 40 grams of HFCSper can– more than the American Medical
Association’s recommended daily maximum for ALL caloric sweeteners. And that’s
without adding in all the corn syrup now found in every type of processed,
pre-packaged food you can think of.
fact, the use of high fructose corn syrup in the U.S. diet increased a
percentbetween 1970 and
2005, according to the latest USDADietary Assessment
of Major Trends in U.S. Food Consumption report. That too is no major
surprise considering that processed foods account for more than 90 percent of
the money Americans spend on their meals.
in all, according to theUSDA’s report,
aboutone-quarter of the
calories consumed by the average American is in the form of added
sugars– the majority of
which comes from high fructose corn syrup.
this is an absolute prescription for disaster. Is it any wonder that we are
suffering epidemics of chronic diseases that are contributing to the economic
collapse, as they require expensive drug and surgical solutions that only
treat the symptoms, but do nothing to address the cause of the
Why High Fructose Corn Syrup IS Worse For You than
you need to lose weight, or if you want to avoid diabetes and heart disease,
fructose is one type of sugar you’ll want to avoid, particularly in the form
of high-fructose corn syrup.
Part of what makes HFCS such
a dangerous sweetener is that it is metabolized to fat in your body far more
rapidly than any other sugar.
According to Dr. Elizabeth Parks,
associate professor of clinical nutrition at UT Southwestern Medical Center
and lead author of astudyon fructose, published in theJournal of Nutritionjust last year:
study shows for the first time the surprising speed with which humans make
body fat from fructose. Once you start the process of fat synthesis from
fructose, it's hard to slow it down. The bottom line of this study is that
fructose very quickly gets made into fat in your body."
occurs because most fats are formed in your liver, and when sugar enters your
liver, it decides whether to store it, burn it or turn it into fat. Fructose,
however, bypasses this process and simply turns into fat.
there’s hard empirical evidence showing that refined man-made fructose like
HFCS metabolizes to triglycerides and adipose tissue, not blood glucose. And
one of themost thorough scientific
analysespublished to date
on this topic found that fructose consumption leads to decreased signaling to
your central nervous system from the hormones leptin and insulin.
insulin and leptin act as key signals in regulating how much food you eat, as
well as your body weight, this suggests that dietary fructose may contribute
to increased food intake and weight gain.
insulin and leptin signaling is also a main cause of diabetes and a host of
other obesity-related conditions.
How HFCS Contributes to Diabetes
addition to everything already mentioned -- including these latest findings
that HFCS consumption can lead to nonalcoholic fatty liver disease, followed
by hepatic insulin resistance and then type 2 diabetes -- research reported at
the 2007 national meeting of the American Chemical Society, foundevidence
that soft drinks sweetened with HFCS may contribute to the development of
diabetesbecause it contains high levels of reactive compounds that trigger
cell and tissue damage that cause diabetes.
tests among 11 different carbonated soft drinks containing HFCS were found to
have ‘astonishingly high’ levels of reactive carbonyls. Reactive carbonyls are
undesirable and highly-reactive compounds associated with “unbound” fructose
and glucose molecules, and are believed to cause tissue damage.
contrast, reactive carbonyls are not present in table sugar because its
fructose and glucose components are “bound” and chemically stable.
carbonyls are elevated in the blood of individuals with diabetes and are
linked to the health complications of diabetes. It is estimated that a single
can of soda contains about five times the concentration of reactive carbonyls
than the concentration found in the blood of an adult person with
How HFCS Contributes to Heart Disease
is also known tosignificantly
raise your triglyceridesand
LDL (bad cholesterol). Triglycerides, the chemical form of fat found in foods
and in your body, are not something you want in excess amounts.
Intense research over the
past 40 years has confirmed that elevated blood levels of triglycerides, known
as hypertriglyceridemia, puts you at an increased risk of heart
Additional Health Dangers of High Fructose Corn
if all of that wasn’t bad enough, fructose also does not contain any enzymes,
vitamins or minerals so it takes these micronutrients from your body while it
assimilates itself for use.
fructose, found in large quantities in HFCS, can interfere with your heart's
use of minerals such as magnesium, copper and chromium.
note that this does not mean you should avoidwhole fruit, however, as it
contains natural fructose together with the enzymes, vitamins and minerals
needed for your body to assimilate the fructose. Eating small amounts of whole
fruit also does not provide a tremendous amount of fructose, and is not likely
to be a problem for most people unless diabetes or obesity is an issue.
GMO corn will radically
increase your risk of developing corn allergies. The problem with corn
allergies are that once you have a corn allergy from GMO corn you will have an
allergy to even healthy organic corn products.
How You Can Drastically Improve Your Overall
you want to drastically improve your health, the answer is quite simple. To
lose weight and reduce your risk of developing metabolic syndrome, diabetes,
and heart disease, STOP drinking soda and processed fruit juices. Switch
topure wateras your beverage of choice and you
will be well on your way to better health.
preserve your health you also need to focus your diet onwhole foods based on
your personal biochemistry, and, if you do purchase packaged foods, become
an avid label reader and avoid foods that contain corn syrup as a main
ByDr. Mercola|March 24 2009
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